Matthew Sharpe

Research

Overview

Dr. Sharpe's research interests focus on medical education and asthma. His work includes development of a fourth-year medical student simulation curriculum and simulated central line project with medical residents. He was co-investigator on a simulated medical student experience where students follow a patient over their 4 years of study as the patient progresses through a chronic and ultimately terminal disease.

He has built collaborations with the department of basic sciences on translational work involving patients with Tylenol-induced liver failure. This group was one of the first to look at the mechanism underlying acetaminophen-induced hepatotoxicity in humans. Their findings were published in the well-respected Journal of Clinical Investigation in 2012.

Currently, Dr. Sharpe's asthma interests have moved more toward active participation at the community education level. He is excited to engage with the communities of Kansas City and work to reduce uncontrolled asthma rates. In addition, he plans to work with National (CMS), State and local agencies on the development of a State of Kansas Asthma Initiative. In collaboration with our allied health partners in respiratory care, I hope to develop a virtual asthma educational platform that can be used to educate health care providers in rural Kansas.

• Antoine, D., J, Jenkins, R., E, Dear, J., W, Williams, D., P, McGill, M., R, Sharpe, M., R, Craig, D., G, Simpson, K., J, Jaeschke, H, Park, B., K. 2020. Retraction notice to "Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity": J Hepatol 56(2012)1070-1079.. Journal of hepatology, 73 (5), 1297
• Ellerbeck, E., F, Nollen, N, Hutcheson, T., D, Phadnis, M, Fitzgerald, S., A, Vacek, J, Sharpe, M., R, Salzman, G., A, Richter, K., P. 2018. Effect of Long-term Nicotine Replacement Therapy vs Standard Smoking Cessation for Smokers With Chronic Lung Disease: A Randomized Clinical Trial.. JAMA network open, 1 (5), e181843. doi:10.1001/jamanetworkopen.2018.1843
• Weemhoff, J., L, Woolbright, B., L, Jenkins, R., E, McGill, M., R, Sharpe, M., R, Olson, J., C, Antoine, D., J, Curry, S., C, Jaeschke, H. 2017. Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.. Liver international : official journal of the International Association for the Study of the Liver, 37 (3), 377-384.
• Burnett, D., M, Vardiman, J., P, Deckert, J., A, Ward, J., L, Sharpe, M., R. 2016. Perception of Exercise-Induced Bronchoconstriction in College Athletes.. Respiratory care, 61 (7), 897-901.
• Xie, Y, McGill, M., R, Cook, S., F, Sharpe, M., R, Winefield, R., D, Wilkins, D., G, Rollins, D., E, Jaeschke, H. 2015. Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.. Xenobiotica; the fate of foreign compounds in biological systems, 45 (10), 921-9.
• Diederich, E, Mahnken, J., D, Rigler, S., K, Williamson, T., L, Tarver, S, Sharpe, M., R. 2015. The Effect of Model Fidelity on Learning Outcomes of a Simulation-Based Education Program for Central Venous Catheter Insertion.. Simulation in healthcare : journal of the Society for Simulation in Healthcare, 10 (6), 360-367.
• Woolbright, B., L, McGill, M., R, Staggs, V., S, Winefield, R., D, Gholami, P, Olyaee, M, Sharpe, M., R, Curry, S., C, Lee, W., M, Jaeschke, H. 2014. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.. Toxicological sciences : an official journal of the Society of Toxicology, 142 (2), 436-44.
• Williams, C., D, Bajt, M., L, Sharpe, M., R, McGill, M., R, Farhood, A, Jaeschke, H. 2014. Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.. Toxicology and applied pharmacology, 275 (2), 122-33.
• McGill, M., R, Staggs, V., S, Sharpe, M., R, Lee, W., M, Jaeschke, H. 2014. Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.. Hepatology (Baltimore, Md.), 60 (4), 1336-45.
• McGill, M., R, Li , F, Sharpe, M., R, Williams, C., D, Curry, S., C, Ma, X, Jaeschke, H. 2014. Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.. Archives of toxicology, 88 (2), 391-401.