Katherine Waugh

Research

Overview

Valid science relies on heterogenous perspectives and values. We therefore strive to be a highly collaborative research laboratory that applies an immunogenetics lens more broadly to developmental biology through an efficient team-oriented systemic approach. This is a surprisingly rare tactic with potential for immediate clinical impact in our era of emerging global infectious disease. For although immunogenetics traditionally mines the genetic basis of immune responses, including identification of genes that potentiate defects of the immune system, it is unusual to come across studies to define variants in immune genes that impact development of other organ systems, as is commonly done in cancer immunology. Towards this end, we capitalize on recent advances in genomics to probe the impacts of inflammatory signaling cascades on organismal growth and development with a focus on immune genes triplicated in trisomy of human chromosome 21 (i.e., Trisomy 21 or “Down syndrome”). Through this work we hope to realize our vision of establishing an innovative yet solid foundation for developing immunomodulatory strategies that facilitate fetal development during high-risk pregnancies.

Mentoring statement: I take great satisfaction in building personalized mentorship programs. A lot of my time and effort are invested in tailored training and I encourage the same commitment from mentees. Available tools are leveraged for more efficient development (i.e., myidp.sciencecareers.org) and evolution (i.e., StrengthsFinder 2.0) of mentorship programs. Mentee projects within the scope of our broader research program can then appeal to their career goals through experiment engagement and guided discussions. Importantly, I work to establish mentorship programs with all trainees, including students and postdoctoral fellows, as well as research technicians, assistants, and associates. The overall lab environment that I strive for is therefore collegial with active learning opportunities available for diverse career trajectories.

• Galbraith, Matthew., D, Rachubinski, Angela., L, Smith, Keith., P, Araya, Paula, Waugh, Katherine., A, Enriquez-Estrada , Belinda, Worek, Kayleigh, Granrath, Ross., E, Kinning, Kohl., T, Eduthan , Neetha., P, Ludwig, Mike., P, Hsieh, Elena., WY, Sullivan, Kelly., D, Espinosa, Joaquin., M. 2023. Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition. Science Advances.
• Waugh, Katherine., A, Minter, Ross, Baxter, Jessica, Chi, Congwu, Galbraith, Matthew., D, Tuttle, Kathryn., D, Eduthan, Neetha., P, Kinning, Kohl., T, Andrysik, Zdenek, Araya, P, Dougherty, Hannah, Dunn, Lauren., N, Ludwig, Mike, Schade, Kyndal., A, Tracy, Dayna, Smith, Keith., P, Granrath, Ross., E, Busquet, Nicolas, Khanal, Santosh, Anderson, Ryan., D, Cox, Liza., L, Enriquez-Estrada , Belinda, Rachubinski, Angela., L, Lyford, Hannah, Britton, Ella., C, Fantauzzo, Katie., A, Orlicky, David., J, Matsuda, Jennifer., L, Song, Kunhua, Cox, Timothy., C, Sullivan, Kelly., D, Espinosa, Joaquin., M. 2023. Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model. Nature Genetics.
• Tuttle, Kathryn., D, Waugh, Katherine., A, Araya, Paula, Minter, Ross, Orlicky, David., J, Ludwig, Mike, Andrysik, Zdenek, Burchill, Matthew., A, Tamburini , Beth., AJ, Sempeck, Colin, Smith, Keith., P, Granrath, Ross., E, Tracy, Dayna, Baxter, Jessica, Espinosa, Joaquin., M, Sullivan, Kelly., D. 2020. JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome. Cell Reports. (20)31396-6.pdf
• Powers, Rani., K, Culp-Hill, Rachel, Ludwig, Mike., P, Smith, Keith., P, Waugh, Katherine., A, Minter, Ross., M, Tuttle, Kathryn., D, Lewis, Hannah., C, Rachubinski, Angela., L, Granrath, Ross., E, Carmona-Iragui , Maria, Wilkerson, Rebecca., B, Kahn, Darcy., E, Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D'Alessandro, Angelo, Costello, James., C, Sullivan, Kelly., D, Espinosa, Joaquin., M. 2019. Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors. Nature Communications.
• Araya, P, Waugh, Katherine., A, Sullivan, Kelly., D, Núñez, Nicolas., G, Roselli, Emiliano, Smith, Keith., P, Granrath, Ross., E, Rachubinski, Angela., L, Enriquez Estrada , Belinda, Butcher, Eric., T, Minter, Ross, Tuttle, Kathryn., D, Bruno, Tullia., C, Maccioni, Mariana, Espinosa, Joaquin., M. 2019. Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity. Proceedings of the National Academy of Sciences.
• Waugh, Katherine., A, Araya, Paula, Pandey, Ahwan, Jordan, Kimberly, Smith, Keith., P, Granrath, Ross., E, Khanal, Santosh, Butcher, Eric., T, Enriquez Estrada , Belinda, Rachubinski, Angela., L, McWilliams, Jennifer., A, Minter, Ross, Dimasi, Tiana, Colvin, Kelley., L, Baturin, Dmitry, Pham, Andrew., T, Galbraith, Matthew., D, Bartsch, Kyle., W, Yeager, Michael., E, Porter, Christopher., C, Sullivan, Kelly., D, Hsieh, Elena., WY, Espinosa, Joaquin., M. 2019. Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome. Cell Reports. (19)31352-X
• Bruno, Tullia., C, Ebner, Peggy., J, Moore, Brandon., L, Squalls, Olivia., G, Waugh, Katherine., A, Eruslanov, Evgeniy., B, Singhal, Sunil, Mitchell, John., D, Franklin, Wilbur., A, Merrick, Daniel., T, McCarter, Martin., D, Palmer, Brent., E, Kern, Jeffrey., A, Slansky, Jill., E. 2017. Antigen-Presenting Intratumoral B Cells Affect CD4+ TIL Phenotypes in Non-Small Cell Lung Cancer Patients. Cancer Immunology Research.
• Waugh, Katherine., A, Leach, Sonia., M, Moore, Brandon., L, Bruno, Tullia., C, Buhrman, Jonathan., D, Slansky, Jill., E. 2016. Molecular Profile of Tumor-Specific CD8+ T Cell Hypofunction in a Transplantable Murine Cancer Model. Journal of Immunology.
• Waugh, Katherine., A, Leach, Sonia., M, Slansky, Jill., E. 2016. Tolerance of Tumor-Specific T cells in Melanoma Metastases. Journal of Clinical and Cellular Immunology.
• Waugh, Katherine., A, Leach, Sonia., M, Slansky, Jill., E. 2015. Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity. Vaccines.